|
|
|
|
|
Common Factor Between Mesothelioma And Money
By KhmengWat.com
Apart from the common “m”, is there anything else in common between Mesothelioma and money? This is no kidding. Mesothelioma is as valid as a legal issue as it is one of the biggest medical concerns since the last century.
The first so called diagnosed case of Mesothelioma came forward in from of this whole world in the 1890s. And the first ever legal step against step to compensate for the cause of Mesothelioma was taken in 1929. Within a gap of around forty years the medical case took a new dimension to form a legal case as well.
Mesothelioma as a disease
You must have a comprehensive idea about Mesothelioma. A severe disorder in the human body that affects the body’s most protective outline covering the crucial internal organs like the abdomen,
|
|
|
|
|
Musculoskeletal center wins $2.2 million for drug safety
The University of Alabama at Birmingham (UAB) Center for Education and Research on Therapeutics (CERTs) has won a $2.2 million federal grant to study the risks and benefits of a newer class of medicines called biologics. These are genetically engineered therapies that target the immune system of patients who have rheumatoid arthritis, Crohn's disease, psoriasis and other autoimmune disorders. (Source: Health News from Medical News Today)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Crohn's disease patients at risk of significant diagnostic radiation exposure
Recent findings published in the November issue of the journal Gut suggest that there are identifiable subsets of patients with Crohn's disease who are at risk of exposure to high levels of diagnostic radiation. Reuters Health Information (Source: Medscape Radiology Headlines)
Prometheus presents new clinical insights into diagnosis of crohn's disease in children from analysis of prometheus(r) ibd serology 7 test results
Prometheus Laboratories Inc., a specialty pharmaceutical and diagnostic company, announced new findings regarding the correlation between serologic markers and the diagnostic predictions of children with Crohn's disease following an analysis of PROMETHEUS(R) IBD Serology 7 test results. (Source: Crohn's News From Medical News Today)
Pfizer announces plan for stem cell unit
FROM IBD NEWS SERVICES (Source: Investor's Business Daily: HEALTH)
Crohn's disease patients at risk of significant diagnostic radiation exposure
NEW YORK (Reuters Health), Nov 18 - Recent findings published in the November issue of the journal Gut suggest that there are identifiable subsets of patients with Crohn's disease who are at risk of exposure to high levels of diagnostic radiation. (Source: AuntMinnie.com Headlines)
Crohn's disease surgeries make steady advances
(New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College) Thousands of Americans suffering from the chronic inflammatory bowel condition known as Crohn's disease are leading longer, healthier lives due to innovative new surgeries, according to experts at NewYork-Presbyterian Hospital/Weill Cornell Medical Center. (Source: EurekAlert! - Cancer)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Musculoskeletal center wins $2.2 million for drug safety
(University of Alabama at Birmingham) The UAB Center for Education and Research on Therapeutics has won a $2.2 million federal grant to study the risks and benefits of a class of drugs called "biologics." These are agents genetically engineered to target the immune system of patients with rheumatoid arthritis, Crohn's disease, psoriasis and other autoimmune disorders. The grant will allow the UAB center to pinpoint which biologics have safety concerns and which work best for specific groups of patients. (Source: EurekAlert! - Biology)
[immunology] thymus leukemia antigen controls intraepithelial lymphocyte function and inflammatory bowel disease
Intestinal intraepithelial lymphocytes (IEL) bear a partially activated phenotype that permits them to rapidly respond to antigenic insults. However, this... (Source: Proceedings of the National Academy of Sciences)
The world in medicine: gut bacteria and crohn disease
(Source: JAMA)
Downregulation of cpi-17 contributes to dysfunctional motility in chronic intestinal inflammation model mice and ulcerative colitis patients
Conclusions CPI-17 downregulation might contribute to the decreased motor function in chronic inflammatory bowel diseases.
Content Type Journal ArticleCategory Alimmentary TractDOI 10.1007/s00535-008-2241-2Authors
Takashi Ohama, The University of Tokyo Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences 1-1-1 Yayoi, Bunkyo-ku Tokyo 113-8657 JapanMasatoshi Hori, The University of Tokyo Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences 1-1-1 Yayoi, Bunkyo-ku Tokyo 113-8657 JapanMasahiko Fujisawa, The University of Tokyo Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences 1-1-1 Yayoi, Bunkyo-ku Tokyo 113-8657 JapanMasaharu Kiyosue, The University of Tokyo Departmen...
Escherichia coli type 1 pili trigger late il-8 production by neutrophil-like differentiated plb-985 cells through a src family kinase- and mapk-dependent mechanism.
Escherichia coli type 1 pili trigger late IL-8 production by neutrophil-like differentiated PLB-985 cells through a Src family kinase- and MAPK-dependent mechanism.
J Leukoc Biol. 2008 Nov 17;
Authors: Semiramoth N, Gleizes A, Turbica I, Sandre C, Gorges R, Kansau I, Servin A, Chollet-Martin S
The innate immune response to enteropathogenic bacteria includes chemokine-induced polymorphonuclear neutrophil (PMN) migration across mucosal epithelia leading to bacterial clearance and resolution of infection. Among these bacteria, diffusely adherent Escherichia coli expressing Afa/Dr fimbriae (Afa/Dr DAEC), causing childhood diarrhea, can promote IL-8-dependent PMN transmigration across cultured intestinal epithelial cell monolayers via MAPK pathway activation. However, interactions b...<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Crohn's disease researchers in plea for study volunteers
PATIENTS with Crohn's disease are being invited to take part in pioneering research that may find the first preventative medicine for their condition. (Source: Scotsman.com News - Health)
Crohn's disease in an african-american population.
Page: 389DOI: 10.1097/MAJ.0b013e31816a5c06Authors: JACKSON, JAMES F. III MD; DHERE, TANVI MD; REPAKA, APARNA MD; SHAUKAT, AASMA MD, MPH; SITARAMAN, SHANTHI MD, PhD (Source: The American Journal of the Medical Sciences)
Predictive value of serologic markers in a population-based norwegian cohort with inflammatory bowel disease
Conclusions: The prevalence of ASCA in CD and pANCA in UC appears markedly lower than in referral-based populations. Even with the low prevalence, our study gives further support to the role of ASCA and pANCA as markers for distinct phenotype and outcome of disease.(Inflamm Bowel Dis 2008) (Source: Inflammatory Bowel Diseases)
Once daily salofalk granules now available in 1.5g sachet for ulcerative colitis
Dr Falk Pharma has today launched Salofalk granules in a new 1.5g sachet. Treatment of active ulcerative colitis once daily is now even easier with the new sachet as it offers patients simpler dosing of one or two sachets a day. A recent study, published in Gut, showed that 80% of patients preferred once daily dosing to three times daily, both of which are efficacious and safe. (Source: Health News from Medical News Today)
Adalimumab may reduce health-care costs for crohn's disease patients
Additional study shows further research needed on 5-ASA's chemopreventative role in ulcerative colitis Inflammatory bowel disease (IBD) is a term that refers to both ulcerative colitis (UC) and Crohn's disease (CD). IBD occurs most frequently in people in their late teens and twenties. There have been cases in children as young as two years old and in older adults in their seventies and eighties; men and women have an equal chance of getting the disease. (Source: Crohn's News From Medical News Today)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
A faster test for the food protein that triggers celiac disease - analytical chemistry journal
Researchers in Spain and the United Kingdom are reporting development of a faster test for identifying the food protein that triggers celiac disease, a difficult-to-diagnose digestive disease involving the inability to digest protein called gluten that occurs in wheat, oats, rye, and barley. The finding could help millions of people avoid diarrhea, bloating, and other symptoms that occur when they unknowingly eat foods containing gluten. (Source: Crohn's News From Medical News Today)
Pfizer announces plan for stem cell unit
FROM IBD NEWS SERVICES (Source: Investor's Business Daily: HEALTH)
Snp-guided microrna maps (mirmaps) of 16 common human disorders identify a clinically accessible therapy reversing transcriptional aberrations of nuclear import and inflammasome pathways.
We report the results of a disease phenocode analysis interrogating the relationships between structural features and gene expression patterns of disease-linked SNPs, microRNAs and mRNAs of protein-coding genes in association to phenotypes of 16 major human disorders, which was enabled by multiple independent studies of up to 451,012 combined samples including 194,258 disease cases and 256,754 controls. SNP sequence homology-guided microRNA maps (MirMaps) identify consensus components of a disease phenocode consisting of 81 SNPs and 17 microRNAs. microRNAs of the consensus set are associated with at least 4 common human diseases (range 4 to 7 diseases) and manifest sequence homology/complementarity to at least 4 distinct disease-linked SNPs (range 4 to 14 SNPs). Nearly all microRNAs (15 of...
Small molecule p38 map kinase inhibitors for the treatment of inflammatory diseases: novel structures and developments during 2006-2008.
This article reviews the patent and journal publication activities during 2006-2008 describing novel small molecule p38alphainhibitors.
PMID: 18991731 [PubMed - in process] (Source: Current Topics in Medicinal Chemistry)
New information guides available for patients diagnosed with ibd
EFCCA launches new series of guides for the one million people across Europe suffering from inflammatory bowel disease (Source: Nursing in Practice)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Small-intestinal manifestations of dextran sulfate sodium consumption in rats and assessment of the effects of
lactobacillus fermentum
br11
Abstract The dextran sulfate sodium (DSS) colitis model has been utilized to screen for novel therapeutics for ulcerative colitis.
Evidence suggests the small intestine may also be affected by DSS. We characterized the effects of DSS on the small intestine
and assessed the potential for Lactobacillus fermentum BR11 to modify or normalize DSS-induced changes. Rats were allocated to three groups, Water + Vehicle, DSS + Vehicle, and
DSS + L. fermentum BR11. BR11 was administered twice daily for 14 days. DSS (2%) was provided from days 7 to 14. Small-intestinal tissue was
analyzed for sucrase activity, histology, and crypt cell proliferation. Increased ileum crypt depth and cell proliferation
was observed in DSS-treated rats compared to contro...
Results of operative management of crohn?s disease: a series of 50 patients managed by one surgeon
Abstract A computer analysis has been made of clinical experience of Crohn?s disease in Australian patients. Between 1950 and 1978,
50 patients were managed for Crohn?s disease by one of the authors (E.S.R.H.). This group represented 3.1. per cent of 1608
patients treated during the same period for primary inflammatory bowel disease. The mean follow-up period was 8.4 years. Thirty-nine
of the 50 patients were female and 11 male. The small intestine was involved in seven patients, large intestine in 17 and
both small and large intestine in 26. Symptoms were related to the anatomic localization of disease. Four patients have died
(two postoperative deaths and two unrelated to Crohn?s disease). Forty-nine of the 50 patients required operative procedures
and 36 underwent...
Total colectomy, mucosal proctectomy, and ileoanal anastomosis
Abstract A safe and practical procedure for total colectomy and mucosal proctectomy with ileonal anastomosis has been developed and
performed by us on 11 patients with adenomatosis coli and two patients with ulcerative colitis. The major features of the
operative procedure are 1) total removal of the rectal mucosa to just above the dentate line; 2) preservation of anorectal
function by a long rectal cuff procedure achieved by rectal mucosal excision from a level just below the sacral promontory,
using a rectal internal stent and gauze packing techniques for rectal mucosal stripping, with, in some patients, an ileal
reservoir added; and 3) prevention of pelvic sepsis by intraoperative rectal irrigation, rectal cuff drainage, and a temporary
defunctioning loop ileostomy. Of ...
Adalimumab may reduce health-care costs for crohn's disease patients
Inflammatory bowel disease (IBD) is a term that refers to both ulcerative colitis (UC) and Crohn's disease (CD). IBD occurs most frequently in people in their late teens and twenties. There have been cases in children as young as two years old and in older adults in their seventies and eighties; men and women have an equal chance of getting the disease. (Source: Huliq Health News)
Treatment of choice for acute severe steroid-refractory ulcerative colitis is colectomy
No abstract. (Source: Inflammatory Bowel Diseases)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Azathioprine is superior to budesonide in achieving and maintaining mucosal healing and histologic remission in steroid-dependent crohn's disease
Conclusions: In patients with steroid-dependent inflammatory Crohn's ileocolitis or proximal colitis who achieve clinical remission with conventional steroids, a 1-year treatment with AZA was superior to BUD in achieving and maintaining mucosal healing and histologic remission.(Inflamm Bowel Dis 2008) (Source: Inflammatory Bowel Diseases)
Persistent retention of colitogenic cd4+ memory t cells causes inflammatory bowel diseases to become intractable
Despite the advent of an age when "malignant" leukemia is cured by bone marrow transplantation, "benign" inflammatory bowel diseases (IBDs) are still intractable lifelong diseases. Why is it that once an IBD develops it lasts a long time? We propose that, the same as in the response to vaccination, immune memory T cells that remember the disease are formed in IBDs and, perceiving them as "benign T-cell leukemia"-like lifelong pathology that hematogenously spreads throughout the body, we here propose that the bone marrow itself, which produces large amounts of the survival factor IL-7, is the reservoir for colitogenic CD4+ memory T cells responsible for the intractability of IBDs.(Inflamm Bowel Dis 2008) (Source: Inflammatory Bowel Diseases)
Iron in water supply linked to inflammatory bowel diseases
The risk of developing ulcerative colitis and Crohn's disease is associated with elevated iron levels in drinking water, according to a study in Norway. Reuters Health Information (Source: Medscape PublicHealth Headlines)
Infliximab as a rescue therapy for hospitalized patients with severe ulcerative colitis refractory to systemic corticosteroids
Dig Surg 2008;25:383-386 (DOI:10.1159/000170882) (Source: Digestive Surgery)
Philips' intelligent pill targets drug development and treatment for digestive tract diseases
At this week's opening of the American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition (Atlanta, USA, November 16-20, 2008) Philips Research will announce its new intelligent pill technology "iPill", targeted at assisting drug development and enabling new therapies for debilitating and life-threatening digestive tract disorders such as Crohn's disease, colitis and colon cancer. (Source: Crohn's News From Medical News Today)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Fda approves deadly enbrel drug for children
(NaturalNews) An FDA advisory panel has recommended the approval of Amgen's immune-suppressing drug Enbrel (generic name etanercept) for the treatment of psoriasis in children, in spite of ongoing concerns that the drug may have lethal side effects.The recommendation came only two days after an independent panel recommended that the FDA strengthen Enbrel's label with warnings about potentially fatal side effects such as anemia, seizures, serious infections, cancer or neurological problems. It also comes as the FDA is investigating whether the entire drug family of which Enbrel is a part increases the risk of cancer in children, particularly lymphoma.The FDA is investigating 30 reports of cancer in children and young adults who have been treated with drugs in the family, known as tumor necr...
Adalimumab may reduce health-care costs for crohn's disease patients
(American Gastroenterological Association) Inflammatory bowel disease is a term that refers to both ulcerative colitis and Crohn's disease. IBD occurs most frequently in people in their late teens and twenties. There have been cases in children as young as two years old and in older adults in their seventies and eighties; men and women have an equal chance of getting the disease. (Source: EurekAlert! - Medicine and Health)
A common barrier defect for celiac disease and ulcerative colitis.
A Common Barrier Defect for Celiac Disease and Ulcerative Colitis.
Gastroenterology. 2008 Nov 12;
Authors: Mannon PJ
PMID: 19013169 [PubMed - as supplied by publisher] (Source: Gastroenterology)
Withdrawal of immunosuppression in crohn's disease treated with scheduled infliximab maintenance.
Withdrawal of Immunosuppression in Crohn's Disease Treated With Scheduled Infliximab Maintenance.
Gastroenterology. 2008 Nov 12;
Authors: Francis G, Duggan A
PMID: 19013168 [PubMed - as supplied by publisher] (Source: Gastroenterology)
The direct and indirect cost burden of crohn's disease and ulcerative colitis.
Page: 1261DOI: 10.1097/JOM.0b013e318181b8caAuthors: Gibson, Teresa B. PhD; Ng, Eliza MD; Ozminkowski, Ronald J. PhD; Wang, Shaohung PhD; Burton, Wayne N. MD; Goetzel, Ron Z. PhD; Maclean, Ross MD, MBA (Source: Journal of Occupational and Environmental Medicine)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
A short-oligonucleotide microarray that allows improved detection of gastrointestinal tract microbial communities
Conclusions:
In this study we demonstrate the design, testing and application of a highly sensitive, short oligonucleotide community microarray. Our approach allows the rapid discrimination of bacteria inhabiting the human GI tract, at taxonomic levels ranging from species to the superkingdom bacteria. The optimised protocol is available at: http://www.ifr.ac.uk/safety/microarrays/#protocols. It offers a high throughput method for studying the dynamics of the bacterial population over time and between individuals. (Source: BMC Microbiology - Latest articles)
Curcumin attenuates inflammation through inhibition of tlr-4 receptor in experimental colitis.
In this study, we investigated the effects of curcumin on the expression of TLR-4 and MyD88, the upstream signaling pathway in experimental colitis induced in the Sprague-Dawley male rats by intra-rectal administration of trinitrobenzenesulfonic acid (TNBS). The animals which received TNBS were divided into two groups: Group 1, received aqueous suspension of curcumin (100 mg/Kg body weight) 2 h prior to inducing colitis, and the treatment was repeated every day for 5 days, and Group 2 and non-colitis (Group 3) animals received phosphate buffered saline (PBS) in a similar fashion. Non-colitis animals (Group 4) received curcumin and served as controls. Animals were sacrificed on day 5 post-TNBS by cervical dislocation, colon was taken out, and cleaned with PBS. Levels of TLR-4, MyD88, and NF...
Molecular pathogenesis of inflammatory bowel disease: relevance for novel therapies
Personalized Medicine , November 2008, Vol. 5, No. 6, Pages 609-626.
The immense load of microorganisms within the gastrointestinal tract is a great challenge for the mucosal immune system. Whereas the vast majority of commensal bacteria should be tolerated, pathogenic organisms have to be attacked. During inflammatory ... (Source: Future Medicine: Personalized Medicine)
Guidelines for the management of inflammatory bowel disease in children in the united kingdom
These clinical guidelines provide an evidence and consensus based document describing good clinical practice for the investigation and treatment of IBD (ulcerative colitis and crohn's disease) in children under the age of 18 years, which will promote more consistent clinical care. (Source: Gastroenterology and Liver Diseases Specialist Library - Inflammatory bowel disease)
Mesalazine granted us fda approval for ulcerative colitis.
(Source: Inpharma)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Does the urinary excretion of alpha1-microglobulin and albumin predict clinical disease activity in ulcerative colitis?
CONCLUSION: THE PRESENT STUDY SUGGESTS THAT, AS WITH CRP, URINARY LEVELS OF ALBUMIN AND alpha1-MG INCREASE DURING THE ACTIVE PERIOD OF UC. DURING THE INACTIVE PERIOD, CONCENTRATIONS OF THESE PARAMETERS ARE COMPARABLE TO CONTROLS. THE MEASUREMENT OF alpha1-MG AND/OR MICROALBUMINURIA COULD PROVIDE INFORMATION ON DISEASE SEVERITY AND RESPONSE TO TREATMENT:
PMID: 19002407 [PubMed - as supplied by publisher] (Source: Advances in Therapy)
Mesalazine granted us fda approval for ulcerative colitis.
Page: 23 (Source: Inpharma Weekly)
Abbott's humira® (adalimumab) data shows fistula healing for up to three years in patients with moderate to severe crohn's disease
New data showed that Abbott's (NYSE: ABT) HUMIRA® (adalimumab) provided long-term treatment of fistulas, with more than half of patients with moderate to severe Crohn's disease experiencing fistula healing at three years, according to clinical research presented today at the United European Gastroenterology Week (UEGW) congress in Vienna. (Source: Health News from Medical News Today)
Selected update: mucosal immunology: mismanaged er stress and inflammation
A dysregulated response to endoplasmic reticulum (ER) stress caused by depletion of the transcription factor XBP1 can lead to inflammatory bowel disease. (Source: Nature Signaling Update)
Helminth antigen-based strategy to ameliorate inflammation in an experimental model of colitis
Inflammatory bowel disease (IBD) is the most common and serious chronic inflammatory condition of the gut. Among the distinct T helper (Th) cell subsets, a Th1 type response is associated predominantly with Crohn's disease (CD) while helminth infections generate a strong Th2 type response. IBD is most prevalent in developed countries but rare in countries where infections with helminths are common. Thus, it has been hypothesized that infection with helminth infection influence the development of CD and recent clinical and experimental studies suggest strongly a beneficial role of helminth infection in IBD. In the present study we examined the effects of rectal submucosal administration of helminth antigens on subsequent experimental colitis. Mice were treated with Trichinella spiralis anti...<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Caution urged over use of anti-tumour necrosis factor drugs in bowel disease patients
Patients with inflammatory bowel disease should carefully discuss the risks and benefits of anti-tumour-necrosis-factor drugs with their doctors before undergoing treatment with these medications, say researchers. (Source: MedWire News - Consumer Health)
Ask the experts: do sex-related differences affect clinical course and outcome in crohn's disease?
Sunanda V. Kane, MD, MSPH, FACG, discusses gender-related issues that may have an impact on clinical course and/or management in Crohn's disease.
Medscape Gastroenterology (Source: Medscape FamilyMedicine Headlines)
Concomitant carcinoid tumor and papillary urothelial neoplasm of low malignant potential in a patient with crohn's disease: a case report.
Page: 1231DOI: 10.1097/MEG.0b013e328302f484Authors: Owczarek, Danuta a; Cibor, Dorota a; Szczepanski, Wojciech b; Kosowski, Bogdan c; Mach, Tomasz a (Source: European Journal of Gastroenterology & Hepatology)
Fight back against inflammatory bowel disease.
Is it ulcerative colitis or Crohn's disease? These gut-wrenching disorders have much in common, but they also differ significantly. Make sure you can sort them out so you're prepared to intervene appropriately.Page: 34DOI: 10.1097/01.NURSE.0000341077.75953.74Authors: Day, Michael W. RN, CCRN, MSN (Source: Nursing)
heart and lungs. The disease is called Mesothelioma that is caused mainly due to inhalation of asbestos dust in the form of airborne particles mostly when your body remains continuously in an environment full of asbestos particles and fibers.
You are right. The next thing you would like to know is how a person will come in contact with such huge amount of asbestos. It is only possible if the person works in an asbestos firm or stays in a place where an asbestos milling company is in close proximity. The first one is a direct threat though the second one can be to some extent considered passive.
What is legal in Mesothelioma?
Till this point it is okay that Mesothelioma is a lethal disorder in the human body and the patient can at the most live for three years from the period of diagnosis of this disease. Till date the Medical reports have given this record yet several researches are taking place across the globe to combat Mesothelioma from its roots. But does it allow you smell something legal in it? Not yet!
Mesothelioma becomes legal because Mesothelioma can be checked completely through some preventive measures. The industries don’t maintain the pollution control measures and compel their workers to suffer from the asbestos dust. Most of the consequences result out of negligence from the authority’s side and ignorance from the patient’s part. Thus a legal case can always be filed and fought. If you as a patient can prove that you are a victim of such a situation that was forcefully imposed on you and you were unaware of the ill consequences, you can earn even millions of dollars as compensation. So did you get the justified way to find the connection between the “m” factor between money and Mesothelioma?
Article Directory: http://www.ddl2khmer.com
www.CambodiaITCity.com
|
Additional
Resources
Mesothelioma Defined And Your Legal Rights
By KhmengWat.com
WHAT IS MESOTHELIOMA? Mesothelioma is a cancer of the mesothelium; the protective sac that covers and protects most internal organs of the body. The mesothelium has two layers, one, which covers Read more...
|
Additional
Resources
Symptoms And Treatments For Mesothelioma
By KhmengWat.com
Mesothelioma is one of the few cancers that don't exhibit symptoms until the cancer reaches the late stage of development and it is at this point that many cases become incurable. It also has Read more...
|
Ashg 2008: gaucher disease mutation carriers at higher risk for parkinson's disease
A multiethnic study on 4 continents found that glucocerebrosidase gene mutations are the most common genetic risk factor for Parkinson's disease. Medscape Medical News (Source: Medscape Medical News Headlines)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Test for lrrk2 mutations in patients with parkinson's disease.
Test for LRRK2 mutations in patients with Parkinson's disease.
Pract Neurol. 2008 Dec;8(6):381-5
Authors: Healy DG, Wood NW, Schapira AH
LRRK2-associated Parkinson's disease is common enough to raise clinical questions such as which patients should be tested and what advice should be given. We discuss practical issues in the light of our experiences with real life Parkinson's disease patients. Neurologists should consider testing LRRK2 in Parkinson's disease patients with affected first degree relatives where the onset is over the age of 40 years. A common G2019S mutation makes genetic testing straightforward and cost-effective. Age-related or reduced genetic penetrance means that LRRK2 mutations are also found in sporadic Parkinson's disease patients; however, at present, ther...
Alteration of eating behaviors in patients with parkinson's disease: possibly overlooked?
Alteration of eating behaviors in patients with Parkinson's disease: Possibly overlooked?
Neurocase. 2008;14(6):480-4
Authors: Miwa H, Kondo T
Patients with Parkinson's disease (PD) occasionally show food cravings and/or compulsive eating that result in significant, undesired weight gain. Dopamine replacement therapy may be the cause of this type of eating disorder. We evaluated 60 consecutive patients to see if they had any alteration of eating patterns after starting levodopa. Among them, five (8.3%) patients exhibited characteristic alterations of food preference following the start of dopamine replacement therapy. One patient showed an undesirable weight gain. Of the five patients exhibiting food preference alterations, all showed increased preference to consume sweet snack...
Regional distribution of tetrahydroisoquinoline derivatives in rodent, human, and parkinson's disease brain.
Regional distribution of tetrahydroisoquinoline derivatives in rodent, human, and Parkinson's disease brain.
J Neurochem. 2008 Dec;107(5):1398-413
Authors: DeCuypere M, Lu Y, Miller DD, LeDoux MS
Several members of the tetrahydroisoquinoline (TIQ) family of monoamine alkaloids can be formed from dopamine or its oxidized metabolites and may be involved in the pathogenesis of monoaminergic cell death in Parkinson's disease (PD). Using enantiomeric-selective high-performance liquid chromatography with electrochemical detection and liquid chromatography with tandem mass spectroscopy, the regional concentrations of several TIQ derivatives, including salsolinols, were determined in mouse, rat, normal human, and PD brain. TIQ derivatives were detected in all regions subjected to analy...
Curry spice curcumin and parkinson's disease? protects against a53t alpha-synuclein-induced toxicity
Johns Hopkins Researchers at Neuroscience 2008 - Curcumin, derived from the curry spice turmeric, has strong antioxidant and anti-inflammatory properties. Both oxidative damage - damage caused by oxygen - and inflammation have been implicated in nerve cell death associated with Parkinson's disease. Now, researchers at the Johns Hopkins University School of Medicine have shown in a laboratory model of Parkinson's disease that curcumin does protect cells from dying. (Source: Nutrition/Agriculture News From Medical News Today)
Mayo clinic develops potential new therapy to stop the progression of parkinson's disease
Mayo Clinic (http://www.mayoclinic.org) researchers have developed a method to reduce the production of alpha-synuclein in the brain. Alpha-synuclein is a protein that is believed to be central to the cause of Parkinson's disease (http://www.mayoclinic.org/parkinsons- disease). (Source: Parkinson's Disease News From Medical News Today)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Static posturography and infraclinical postural instability in early-stage parkinson's disease
No abstract. (Source: Movement Disorders)
Mayo clinic develops potential new therapy to stop the progression of parkinson's disease
Mayo Clinic researchers have developed a method to reduce the production of alpha-synuclein in the brain. Alpha-synuclein is a protein that is believed to be central to the cause of Parkinson's disease. (Source: Mayo Clinic Research News)
Mayo clinic develops potential new therapy to stop the progression of parkinson's disease
Mayo Clinic researchers have developed a method to reduce the production of alpha-synuclein in the brain. Alpha-synuclein is a protein that is believed to be central to the cause of Parkinson's disease. (Source: News from Mayo Clinic)
Novel atp13a2 variant associated with parkinson disease in taiwan and singapore
Conclusions: A rare variant of the ATP13A2 was associated with an increased risk of Parkinson disease among ethnic Chinese in Asia. Further studies are needed to clarify the functional role of this genetic risk factor.
GLOSSARY: cDNA = complementary DNA; EOPD = early onset Parkinson disease; ER = endoplasmic reticulum; RT-PCR = reverse-transcriptase PCR; SNP = single nucleotide polymorphism. (Source: Neurology)
Cognition following bilateral deep brain stimulation surgery of the subthalamic nucleus for parkinson's disease
Parkinson's disease (PD) is a neurodegenerative disorder characterized by significant motor dysfunction and various non-motor disturbances, including cognitive alterations. Deep brain stimulation (DBS) is an increasingly utilized therapeutic option for patients with PD that yields remarkable success in alleviating disabling motor symptoms. DBS has additionally been associated with changes in cognition, yet the evidence is not consistent across studies. The following review sought to provide a clearer understanding of the various cognitive sequelae of bilateral subthalamic nucleus (STN) DBS while taking into account corresponding neuroanatomy and potential confounding variables.A literature search was performed using the following inclusion criteria: (1) at least five subjects followed for ...<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Headache of a diagnosis: frontotemporal pain and inflammation associated with osteolysis.
Authors: Tacon LJ, Parkinson JF, Hudson BJ, Brewer JM, Little NS, Clifton-Bligh RJ
A 62-year-old woman presented with left frontotemporal pain, scalp tenderness and raised levels of inflammatory markers. Temporal arteritis was considered likely, and symptoms resolved with prednisone therapy. This delayed diagnostic bone biopsy until a soft tissue abscess formed, and Pott's puffy tumour associated with Prevotella osteomyelitis of the frontal bone was diagnosed. This case highlights the value of early histopathological examination, and is a reminder of a condition seen frequently in the pre-antibiotic era.
PMID: 19012561 [PubMed - in process] (Source: Med J Aust)
An optimized method for histological detection of dopaminergic neurons in drosophila melanogaster
Parkinson's disease (PD) affects >1 million Americans and is marked by the loss of dopaminergic neurons in the substantia nigra. PD has been linked to two causative factors: genetic risks (hereditary PD) and environmental toxins (idiopathic PD). In recent years, considerable effort has been devoted to the development of a Drosophila model of human PD that might be useful for examining the cellular mechanisms of PD pathology by genetic screening. In 2000, Feany and Bender reported a Drosophila model of PD in which transgenic flies expressing human mutant -synuclein exhibited shortened life spans, dopaminergic losses, Parkinsonian behaviors, and Lewy bodies in surviving dopaminergic neurons. Since then, a number of studies have been published that validate the model or build on it; conver...
Amnestic mild cognitive impairment in parkinson's disease: a brain perfusion spect study
The purpose of this study was to investigate cortical dysfunction in Parkinson's disease (PD) patients with amnestic deficit (PD-MCI). Perfusion single photon emission computed tomography was performed in 15 PD-MCI patients and compared (statistical parametric mapping [SPM2]) with three groups, i.e., healthy subjects (CTR), cognitively intact PD patients (PD), and common amnestic MCI patients (aMCI). Age, depression, and UPDRS-III scores were considered as confounding variables. PD-MCI group (P < 0.05, false discovery rate-corrected for multiple comparisons) showed relative hypoperfusion in bilateral posterior parietal lobe and in right occipital lobe in comparison to CTR. As compared to aMCI, MCI-PD demonstrated hypoperfusion in bilateral posterior parietal and occipital areas, mainly rig...
Microsubthalamotomy effect at day 3: screening for determinants
A microsubthalamotomy (mSTN) effect has been frequently reported after implantation that improves Parkinson's motor disability. It is usually believed that mSTN effect reflects the post-traumatic tissue reaction within the STN. However, it has never, to our knowledge, been reported whether pre and intraoperative factors could predict this mSTN effect. Preoperative clinical characteristics, that is, age, disease duration, Mattis Dementia Rating Scale score, levodopa responsiveness, severity of motor fluctuations and dyskinesia, and intraoperative parameters, that is, the number of tracks, distance of typical STN neuronal activity recorded along all microelectrodes, and along the definitive electrodes, were assessed in 40 consecutive PD patients submitted for STN stimulation. Multiple stepwi...
Allied health care in parkinson's disease: referral, consultation, and professional expertise
There is evidence for the efficacy of allied health care in Parkinson's disease (PD). However, barriers exist that hamper implementation of evidence into daily practice. We conducted a survey to investigate: (1) to what extent PD patients currently utilize allied health care for relevant problems in the core areas of allied health care and (2) the level of PD-specific expertise among allied health professionals. Questionnaires were sent to 260 patients and 297 allied health professionals. Referral rates were 63% for physical therapy, 9% for occupational therapy, and 14% for speech therapy. PD patients with problems that can potentially be alleviated by input from allied health professionals are often not being referred. Furthermore, most patients were treated by allied health professionals...<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Alzheimer's, parkinson's diseases could be halted by protecting neurons
Researchers at Southern Methodist University (SMU) and The University of Texas at Dallas (UTD) have identified a group of chemical compounds that slow the degeneration of neurons, a condition behind old-age diseases like Alzheimer's, Parkinson's and amyotrophic lateral sclerosis (ALS). Their findings are featured in the November 2008 edition of Experimental Biology and Medicine. (Source: Health News from Medical News Today)
Protecting neurons could halt alzheimer's, parkinson's diseases
Researchers have identified a group of chemical compounds that slow the degeneration of neurons, a condition behind old-age diseases like Alzheimer's, Parkinson's and amyotrophic lateral sclerosis (ALS). (Source: ScienceDaily Headlines)
Dance class 'uplifting' for parkinson's patients
Pity is not for the students with Parkinson's who study dance at the Mark Morris Dance Group in Brooklyn. Not when one student, well into his 70s, bent crookedly in his chair, lifts his arms gently skyward to the strains of Pachelbel's Canon in D Major. (Source: Health Behavior News Digest)
Notice to extend expiration date for par-06-058, morris k. udall parkinsons disease centers of excellence (p50)
Notice from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Oxford biomedica announces two scientific presentations of prosavin in parkinson's disease
– 16th Annual Congress of European Society of Gene and Cell Therapy –
– 38th Annual Meeting of Society for Neuroscience –
Oxford, UK – 14 November 2008: Oxford BioMedica (LSE: OXB), a leading gene therapy company,... (Source: Drugs.com - Clinical Trials)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Royal assent for human fertilisation and embryology act
New laws that will help maintain the UK's position as a world leader in embryo research, enable scientists to investigate cures for serious illnesses such as Parkinson's disease and regulate assisted reproductive treatments, received Royal Assent today. The new Human Fertilisation and Embryology Act updates the 1990 law to ensure that it is fit for purpose in the 21st Century and keeps the UK at the forefront of developments in treatment and research. (Source: Fertility News From Medical News Today)
A window into parkinson's disease
A new study being published in this Friday's online edition of Cell will help answer the question, what causes Parkinson's disease? One of the most pressing questions in the medical research into Parkinson's disease is what causes the sensitive cells in the brain to die in the first place. (Source: Parkinson's Disease News From Medical News Today)
Real-time analysis of amyloid fibril formation of {alpha}-synuclein with a fibrillation state-specific fluorescent probe of jc-1
α-Synuclein is a pathological component of Parkinson's disease (PD) by participating in the Lewy body formation. JC-1 has been shown to interact with α-synuclein at the acidic C-terminal region with Kd of 2.6 μM. JC-1 has discriminated the fibrillation states of α-synuclein - monomeric, oligomeric intermediate, and fibrillar forms - by emitting the enhanced binding fluorescence of different colors at 590 nm, 560 nm, and 538 nm, respectively, with the common excitation at 490 nm. The fibrillation state-specific interaction of JC-1 allowed us to perform real-time analyses of the α-synuclein fibrillation in the presence of iron as a fibrillation inducer, rifampicin as a fibrillation inhibitor, baicalein as a defibrillation agent, and dequalinium as a protofi...
Brain stimulation may ease anxiety disorder
November 12, 2008 NEW YORK - The same kind of deep brain stimulation used to treat some patients for Parkinson's disease also helped a few people suffering from obsessive-compulsive disorder, French scientists reported. (Source: PsycPORT.com)
[research papers] poor attentional function predicts cognitive decline in patients with non-demented parkinson's disease independent of motor phenotype
Conclusion:
PIGD phenotype and attention deficits are independently associated with a greater rate of cognitive decline in patients with non-demented PD. We propose that subtle attentional deficits in patients with non-demented PD predict subsequent cognitive impairment. (Source: Journal of Neurology, Neurosurgery & Psychiatry)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
[research papers] amyloid load in parkinson's disease dementia and lewy body dementia measured with [11c]pib positron emission tomography
Conclusion:
This study suggests that amyloid load is significantly raised in over 80% of subjects with DLB, while amyloid pathology is infrequent in PDD. These in vivo PET findings suggest that the presence of amyloid in DLB could contribute to the rapid progression of dementia in this condition and that anti-amyloid strategies may be relevant. (Source: Journal of Neurology, Neurosurgery & Psychiatry)
[short reports] pathological description of a non-motor variant of multiple system atrophy
We report a patient with pathologically confirmed MSA who presented with a longstanding history of stridor, RBD and autonomic disturbances but did not develop overt parkinsonism or cerebellar signs. This case illustrates that MSA may present clinically without its cardinal motor symptoms, and that stridor and RBD may be clues to recognise the disease in a patient with autonomic failure. (Source: Journal of Neurology, Neurosurgery & Psychiatry)
[postscript] intractable facial pain in advanced parkinson's disease alleviated by subthalamic nucleus stimulation
(Source: Journal of Neurology, Neurosurgery & Psychiatry)
[postscript] impact of standard of care for psychosis in parkinson disease
(Source: Journal of Neurology, Neurosurgery & Psychiatry)
Correlation between changes in csf dopamine turnover and development of dyskinesia in parkinson's disease.
Correlation between changes in CSF dopamine turnover and development of dyskinesia in Parkinson's disease.
Parkinsonism Relat Disord. 2008 Nov 14;
Authors: Lunardi G, Galati S, Tropepi D, Moschella V, Brusa L, Pierantozzi M, Stefani A, Rossi S, Fornai F, Fedele E, Stanzione P, Hainsworth AH, Pisani A
To assess possible differences in dopamine metabolism that could parallel disease progression in Parkinson's disease (PD), we measured dopamine (DA) and its metabolites in the cerebrospinal fluid (CSF) in PD patients at different stages of disease: de novo (DEN), advanced not showing dyskinesias (ADV), and advanced with dyskinesias (DYS). DA, homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC) were significantly higher in DEN patients compared with other groups. A negati...<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Protecting neurons could halt alzheimer's
Scientists at Southern Methodist University (SMU) and The University of Texas at Dallas (UTD) have identified a group of chemical compounds that slow the degeneration of neurons, a condition behind old-age diseases like Alzheimer's, Parkinson's and amyotrophic lateral sclerosis (ALS). Their findings are featured in the November 2008 edition of Experimental Biology and Medicine SMU Chemistry Professor Edward R. Biehl and UTD Biology Professor Santosh D'Mello teamed to test 45 chemical compounds. Four were found to be the most potent protectors of neurons, the cells that are core components of the human brain, spinal cord and peripheral nerves........ (Source: Medicineworld.org: New Article Alert)
Dance class 'uplifting' for parkinson's patients
Pity is not for the students with Parkinson's who study dance at the Mark Morris Dance Group in Brooklyn. They're experiencing ... (Source: USATODAY.com Health)
Desperate big pharma pushing to double statin sales
This study will be used to promote the sale of dangerous statin drugs to double the current number taking them (which is now at 17 million). First a person will need a test to see if they even have elevated CRP, which of course implies someone pays for the test. The leader of the Jupiter study, Dr. Paul M. Ridker, by some strange coincidence is the co-inventor of the CRP test. Does anyone smell a financial rat?Exercise Reduces CRP, Extends Life, and Doesn't Cost AnythingI'm all in favor of anyone reducing their inflammation level to enhance their health. After all, life can rack up a lot of wear and tear. There is no one pill that will fix the wear and tear in your life. You need adequate rejuvenating sleep, good stress management skills, a healthy diet, and exercise. It is actually a proj...
'brain pacemaker' may ease parkinson's, ocd
A treatment designed to treat the tremors associated with Parkinson's disease is showing some promise for those suffering from obsessive-compulsive disorder, but not without downsides. (Source: WDSU.com - Health)
Transplanted dopaminergic neurons develop pd pathologic changes: a second case report
This report describes pathological changes within the grafted neurons of another patient with Parkinson's disease (PD) who died 14 years posttransplantation. Although numerous healthy appearing grafted neurons were present at this long-term time point, some displayed Lewy bodies as evidenced by alpha-synuclein, ubiquitin, and thioflavin-S staining. Additionally, there was a general loss of dopamine transporter-immunoreactivity in grafted neurons. Some grafted cell displayed a loss of tyrosine hydroxylase. These data support the emerging concept that PD-like pathology is seen in young grafted neurons when they survive long term. © 2008 Movement Disorder Society (Source: Movement Disorders)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Efficient derivation of functional dopaminergic neurons from human embryonic stem cells on a large scale
Authors: Myung-Soo Cho, Dong-Youn Hwang
& Dong-Wook Kim
Cell-replacement therapy using human embryonic stem cells (hESCs) holds great promise in treating Parkinson's disease. We have recently reported a highly efficient method to generate functional dopaminergic (DA) neurons from hESCs. Our method includes a unique step, the formation of spherical neural masses (SNMs), and (Source: Nature Protocols)
Protecting neurons could halt alzheimer's, parkinson's diseases
(Southern Methodist University) Scientists from two Texas universities have identified promising lead chemical compounds for the treatment of neurodegenerative disorders like Alzheimer's and Parkinson's diseases, major and growing health problems as the human life span increases. (Source: EurekAlert! - Biology)
Neuroprotective effects of chalcones from myracrodruon urundeuva on 6-hydroxydopamine-induced cytotoxicity in rat mesencephalic cells.
Neuroprotective Effects of Chalcones from Myracrodruon urundeuva on 6-Hydroxydopamine-Induced Cytotoxicity in Rat Mesencephalic Cells.
Neurochem Res. 2008 Nov 13;
Authors: Nobre-Júnior HV, Oliveira RA, Maia FD, Nogueira MA, de Moraes MO, Bandeira MA, Andrade GM, Viana GS
In the present work, we showed that a chalcone-enriched fraction (CEF) isolated from the stem bark of a Brazilian medicinal plant, Myracrodruon urundeuva, presents neuroprotective actions on 6-hydroxydopamine (6-OHDA)-induced neuronal cell death, in rat mesencephalic cells. In the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium] assay, which is an index of cell viability, CEF (1-100 mug/ml) reversed in a concentration-dependent manner the 6-OHDA-induced cell death. While cells exposed to 6-OHDA ...
Dancing class moves parkinson's patients to a better place
Pity is not for the students with Parkinson's who study dance at the Mark Morris Dance Group in Brooklyn. They're experiencing ... (Source: USATODAY.com Health)
Study: brain stimulation may ease anxiety disorder
NEW YORK (AP) -- The same kind of deep brain stimulation used to treat some patients for Parkinson's disease also helped a few people suffering from obsessive-compulsive disorder, French scientists reported.... (Source: AP Top Health News)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Study: brain stimulation reduces obsessive-compulsive disorder but with risk of side effects
NEW YORK (AP) _ The same kind of deep brain stimulation used to treat some patients for Parkinson's disease also helped a few people suffering from obsessive-compulsive disorder, French scientists reported.
Their study involved only 16 patients, but in... (Source: OrlandoSentinel: Medical Research)
The therapeutical potential of alpha-synuclein antiaggregatory agents for dementia with lewy bodies.
Authors: Beyer K, Ariza A
Dementia with Lewy bodies (DLB), the second most frequent cause of dementia after Alzheimer disease (AD), is characterized by the widespread distribution of Lewy bodies in virtually every brain area. Clinically, DLB is distinguished from AD by fluctuating cognition, prominent visual hallucinations and parkinsonism, and from Parkinson disease, by the appearance of parkinsonism within one year of cognitive or behavioral decline. The main component of Lewy bodies is alpha-synuclein. Accumulating evidence suggests that its aggregation constitutes one of the first steps preceeding Lewy body formation, so that antiaggregation strategies would be very useful to prevent alpha-synuclein fibril formation. Main therapies nevertheless applied up to the present remain symp...
£2 million clinical trials funding for alzheimer's and parkinson's research
Researchers from the Peninsula Medical School, Plymouth Hospitals NHS Trust and the University of Plymouth, have received a grant funding of £2million over the next five years from the National Institute for Health Research (NIHR) to investigate new ways of developing clinical trials for the treatment of Alzheimer's disease and Parkinson's disease. (Source: Alzheimer's / Dementia News From Medical News Today)
Ultrasound treatment of cutaneous side-effects of infused apomorphine: a randomized controlled pilot study
Apomorphine hydrochloride is a dopamine agonist used in the treatment of advanced Parkinson's disease. Its administration by subcutaneous infusions is associated with the development of nodules that may interfere with absorption of the drug. This pilot study assessed the effectiveness of ultrasound (US) in the treatment of these nodules. Twelve participants were randomly assigned to receive a course of real or sham US on an area judged unsuitable for infusion. Following treatment, no significant change was observed in measures of tissue hardness and tenderness. However, 5 of 6 participants receiving real US rated the treated area suitable for infusion compared with the 1 of 6 receiving sham US. Sonographic appearance improved in both groups, but more substantially in the real US group. Pow...
Endogenous regeneration in parkinson's disease: do we need orthotopic dopaminergic neurogenesis?
(Source: Stem Cells)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Noggin enhances dopamine neuron production from human embryonic stem cells and improves behavioral outcome after transplantation into parkinsonian rats
Symptoms of Parkinson's disease have been improved by transplantation of fetal dopamine neurons recovered from aborted fetal tissue, but tissue recovery is difficult. Human embryonic stem cells may provide unlimited cells for transplantation if they can be converted to dopamine neurons and survive transplantation into brain. We have found that the bone morphogenic protein antagonist Noggin increased the number of dopamine neurons generated in vitro from human and mouse embryonic stem cells differentiated on mouse PA6 stromal cells. Noggin effects were seen with either early (for mouse, days 0–7, and for human, days 0–9) or continuous treatment. After transplant into cyclosporin-immunosuppressed rats, human dopamine neurons improved apomorphine circling in direct relation to the...
[basic and translational research] association of increased telomere lengths in limited scleroderma, with a lack of age-related telomere erosion
Conclusions:
This is the first report of maintenance of telomere lengths in an autoimmune disease state. These data indicate aberrant telomere biology and irregular biological ageing from the fifth decade of life. These findings provide insight into compromised DNA damage repair in lcSSc. Whether these observations indicate a causal or consequential relationship requires further investigation. This in turn, may provide potential novel targets for therapeutic intervention. (Source: Annals of the Rheumatic Diseases)
Bowel movement frequency in late-life and substantia nigra neuron density at death
Constipation is associated with future risk of Parkinson's disease (PD) and with incidental Lewy bodies (LB) in the locus ceruleus or substantia nigra (SN). Our purpose is to examine the independent association between bowel movement frequency in late-life and postmortem SN neuron density. Bowel movement frequency was assessed in the Honolulu-Asia Aging Study from 1991 to 1993 in 414 men aged 71 to 93 years with later postmortem evaluations. Brains were examined for LB in the SN and locus ceruleus and neurons were counted in four quadrants from a transverse section of SN. In nonsmokers, neuron densities (counts/mm2) for men with >1, 1, and (Source: Movement Disorders)
Buche-k and apoe [epsi]4 allele frequencies in lewy body dementias, and influence of genotype and hyperhomocysteinemia on cognitive decline
Apolipoprotein E (APOE) [epsiv]4 and butyrylcholinesterase-K (BuChE-K) are associated with an increased risk for Alzheimer's disease. The primary objective was to evaluate frequencies of these alleles in dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD). A secondary objective was to evaluate influences on rate of cognitive decline. This analysis used data from participants consenting to pharmacogenetic testing in placebo-controlled rivastigmine studies. Allele frequencies in DLB and PDD were compared using logistic regression. Within the PDD placebo sample, associations with cognitive decline were evaluated (the DLB sample was too small for these evaluations). Fifty-seven DLB and 323 PDD subjects provided APOE and BuChE data. Allelic frequencies were higher in DLB, rel...
|
