How To Make A Bow And Arrow
By KhmengWat.com
It's easy to make your own archery kit, once you have the right equipment. For this you need: a 5-foot branch and a 1 or 2 foot branch for the arrow; hemp string; feathers; flint stone or metal; Read more...
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Heart Attack: Causes, And Treatment
By KhmengWat.com
A heart attack occurs when blood flow to a section of heart muscle becomes blocked. If the flow of blood isn’t restored quickly, the section of heart muscle becomes damaged from lack of oxygen and begins to die. Coronary arteries are blood vessels that supply the heart muscle with blood and oxygen. Blockage of a coronary artery deprives the heart muscle of blood and oxygen, causing injury to the heart muscle. Injury to the heart muscle causes chest pain and pressure. If blood flow is not restored within 20 to 40 minutes, irreversible death of the heart muscle will begin to occur. A heart attack often causes severe and crushing pain in the middle of the chest. This pain may then travel from the chest to the neck, jaw, ears, arms, and wrists. The person may also be cold and clammy, and their skin may appear pale and grey in color.
Causes of Heart Attack
High Blood Pressure, or hypertension, is a condition in which blood pressure levels are above the normal range. Blood pressures of 120-139 mm Hg and/or 80-89 mm Hg are considered prehypertension. Blood
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Diagnosing adrenal insufficiency.
Page: 3281DOI: 10.1097/CCM.0b013e31818f2962Authors: Alaniz, Cesar PharmD; Arbor, Ann MI; Hyzy, Robert MD (Source: Critical Care Medicine)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Normal overall mortality in addison's disease, but young patients are at risk of premature death.
Conclusion: Addison's disease is still a potentially lethal condition, with excess mortality in acute adrenal failure, infection and sudden death in patients diagnosed at young age. Otherwise, the prognosis is excellent for patients with Addison's disease.
PMID: 19011006 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Making sense of sibling responsibility for family caregiving
As the population in the United States and around the globe ages, families are faced with decisions about caregiving for elderly parents. Research suggests that daughters often take on these stressful caregiving responsibilities, with varying levels of help from siblings. In this article, we examine these sibling relationships within the caregiving context, considering the ways in which siblings negotiate the division of tasks for elderly parents and make sense of siblings who provide little help in caregiving activities. Our content analysis of interviews with 25 family caregivers indicated that there was little negotiation of caregiving tasks. Furthermore, family caregivers make sense of sibling participation in caregiving in three ways. First, some caregivers account for caregiving as a...
A case of non-hodgkin?s lymphoma primary arising in both adrenal glands associated with adrenal failure
Abstract It is known that adrenal insufficiency is one of the complications in primary adrenal lymphoma, especially those with bilateral
adrenal involvement. A 73-year-old man was referred for general fatigue and high fever to the nearest hospital. The patient
was transferred to our hospital for evaluation of bilateral adrenal tumors and hyponatremia. He was diagnosed as having non-Hodgkin?s
lymphoma (NHL) with primaries arising in both adrenal glands. Primary adrenal lymphoma (PAL) is a rare extra-nodal NHL. Although
an appropriate treatment of this disease has not been established, our case has demonstrated that the combination of rituximab
and THP-COP chemotherapy could be administered, and that it improved clinical manifestations. This case raises the suggestion
that...
Jackie's tale sets alarm bells ringing
Last week I failed to distinguish satisfactorily between the fantastical miasmatic theory of disease in the middle ages and the fantastical miasmatic theory of disease as meant by some homeopaths. This made no difference to my argument - that the science of a disease is more interesting than made up nonsense about it - but it was an error, it was mine, and there is no ignominy in clarifying that. So you're reading Woman's Own, and you get to the "Real life - health" pages, and you see "Most people jump when the phone rings unexpectedly, but for Jackie Dewhurst, 39, it could be deadly". This was a first person story about Addison's disease, a disorder of the adrenal glands, under the headline A Phone Call Could Kill Me. "Now I have to avoid stressful situations at all costs," says Jackie, "...
Acute relative adrenal insufficiency after aneurysmal subarachnoid hemorrhage.
Page: 645DOI: 10.1227/01.NEU.0000325728.50939.15Authors: Weant, Kyle A. Pharm.D.; Sasaki-Adams, Deanna M.D.; Dziedzic, Kathryn Pharm.D.; Ewend, Matthew M.D. (Source: Neurosurgery)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
[should etomidate still be used?]
[Should etomidate still be used?]
Ann Fr Anesth Reanim. 2008 Nov 1;
Authors: Payen JF, Vinclair M, Broux C, Faure P, Chabre O
Etomidate blocks the cortisol synthesis by specifically inhibiting the activity of 11beta-hydroxylase, resulting in a primary adrenal insufficiency. Therefore, a serum accumulation of 11beta-deoxycortisol and a low secretion of serum cortisol must be required as diagnostic criteria to assign that adrenal impairment to the drug. These requirements have been rarely fulfilled in studies exploring the contribution of etomidate to the adrenal insufficiency despite numerous causes of adrenal derangement. In critically ill patients without sepsis, a single dose of etomidate results in a wide adrenal inhibition, reversible in 48h after etomidate administration. ...
Refeeding syndrome
We report a case of a fifty-year-old male who was admitted with a three month history of increasing weakness, prostration, decreasing appetite and inability to swallow. The patient was a chronic alcoholic, unemployed, and of very poor socioeconomic background. The patient was initially investigated for upper GI malignancy, Addisons disease, bulbar palsy and other endocrinopathies. Concurrent management was started for severe electrolyte abnormalities and enteral nutritional supplementation was begun. By the fourth day of feeding patient developed severe hypophosphatemia and other life-threatening features suggesting refeeding syndrome. The patient was managed for the manifestations of refeeding syndrome. A final diagnosis of chronic alcoholic malnutrition with refeeding syndrome was made. ...
Topical treatment of uveitis resulting in adrenal insufficiency
Conclusion: When topical corticosteroids are used over longer periods, hypophysis-pituitary-adrenal (HPA) function should be carefully monitored. (Source: Acta Paediatrica)
Incorporation of block copolymer micelles into multilayer films for use as nanodelivery systems
Timothy Addison, Olivier J. Cayre, Simon Biggs, Steven P. Armes, and David YorkWeb Release Date: Tue, 28 Oct 2008 00:00:00 EDT (Research Article) DOI: 10.1021/la802396g (Source: Langmuir)
Diagnosis of secondary adrenal insufficiency in patients with hypothalamic-pituitary disease: comparison between serum and salivary cortisol during the high-dose short synacthen test.
Conclusion. We suggest the determination of basal SeC or SaC as first-line test. In comparison to the ITT, the HDT has only limited value in screening for alterations of the HPA axis. If the HDT is performed, sampling may be limited to 30 min post-synacthen, using either SeC or SaC. Due to the ease of collection and the independence of binding proteins, SaC may be preferable.
PMID: 18952762 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Cosyntropin-stimulated salivary cortisol in hospitalized patients with hypoproteinemia
This study used dynamic testing of salivary cortisol levels to evaluate adrenal function in hospitalized patients
with low/low-normal plasma protein concentration in whom adrenal insufficiency was suspected. Twenty-eight patients with low
serum albumin and proteins hospitalized for acute illness were evaluated for decreased adrenocortical function because of
clinical presentations suspicious for adrenal insufficiency. Baseline and post cosyntropin-stimulated levels of serum total
and salivary cortisol levels were assessed. Data were gathered by a retrospective analysis of medical records. Eight patients
had normal peak serum total and salivary cortisol responses, consistent with intact adrenocortical function. Five patients
had abnormal peak serum total and salivary cortisol response...
A coding polymorphism in nalp1 confers risk for autoimmune addison's disease and type 1 diabetes
A coding polymorphism in NALP1 confers risk for autoimmune Addison's disease and type 1 diabetes
Genes and Immunity advance online publication, October 23, 2008. doi:10.1038/gene.2008.85
Authors: N F Magitta, A S Bøe Wolff, S Johansson, B Skinningsrud, B A Lie, K-M Myhr, D E Undlien, G Joner, P R Njølstad, T K Kvien, Ø Førre, P M Knappskog
& E S Husebye (Source: Genes and Immunity)
[pituitary necrosis and antiphospholipid syndrome.]
We report the case of a 27-year-old woman, victim of a stroke leading to double vision and intracranial hypertension. Magnetic resonance imaging showed a macro-adenoma with hemorrhage of a suprasellar lesion. Hormone assessment showed hyper prolactinemia with positive anticardiolipin antibody. Our case is the second reported associating APS with apoplexy. We discuss the clinical, biological and radiological features observed in our case. We conclude that APS should be searched for whenever a history of adenoma with apoplexy is found associated with recurrent thrombosis.
PMID: 18937932 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Adjunctive therapies in severe sepsis and septic shock: current place of steroids
This article reviews recent publications,
actual recommendations, ongoing discussions, and future perspectives.
Content Type Journal ArticleDOI 10.1007/s11908-008-0058-zAuthors
Didier Keh, Charité Universitaetsmedizin Berlin Department of Anesthesiology and Critical Care Medicine, Campus Virchow-Clinic 13353 Berlin GermanySteffen Weber-CarstensOlaf Ahlers
Journal Current Infectious Disease ReportsOnline ISSN 1534-3146Print ISSN 1523-3847
Journal Volume Volume 10
Journal Issue Volume 10, Number 5 / September, 2008 (Source: Current Infectious Disease Reports)
Pituitary-adrenal function in patients with acute subarachnoid hemorrhage: a prospective cohort study
Conclusions:
Calculation of serum free cortisol concentration was not helpful in identifying patients with potential hypocortisolism. SAH severity did not affect cortisol concentrations, possibly indicating relative pituitary-adrenal insufficiency in patients with more severe bleeding.
Trial registration: ClinicalTrials.gov Identifier NCT00614887. (Source: Critical Care)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Megestrol acetate-induced adrenal insufficiency
We present the case of a 74-year-old woman with infiltrating ductal breast carcinoma
refractory to prolonged hormonal treatment with megestrol acetate, presenting with adrenal insufficiency.
Content Type Journal ArticleCategory Case ReportsDOI 10.1007/s12094-008-0188-7Authors
Paula González Villarroel, Complejo Hospitalario Universitario de Vigo Medical Oncology Department Vigo SpainIsaura Fernández Pérez, Complejo Hospitalario Universitario de Vigo Medical Oncology Department Vigo SpainConcepción Páramo, Complejo Hospitalario Universitario de Vigo Endocrinology Department Vigo SpainMarta Gentil González, Complejo Hospitalario Universitario de Vigo Medical Oncology Department Vigo SpainBeatriz Carnero López, Complejo Hospitalario Universitario de Vigo Medical Oncology Departme...
Iatrogenic cushing?s syndrome and secondary adrenal insufficiency after a single intra-articular administration of triamcinolone acetonide in hiv-infected patients treated with ritonavir
Abstract The development of an iatrogenic Cushing?s syndrome (ICS) followed by secondary adrenal failure remains an exceptional event
after a single dose administration of a synthetic glucocorticoid. Medical attention has been drawn recently on the possible
impact of ritonavir-based antiretroviral regimens on the systemic deleterious effects of a chronic administration of corticosteroids
in HIV-infected patients. Three HIV-infected patients treated by a ritonavir-boosted protease inhibitor (PI) regimen received
a single intra-articular injection of 40 mg triamcinolone acetonide in our university hospital. The three patients rapidly
developed signs and symptoms of ICS followed by secondary adrenal insufficiency. Special attention must be paid when a single
administra...
Do cortisol concentrations predict short-term outcomes in extremely low birth weight infants?
CONCLUSIONS. Low cortisol concentrations were not predictive of adverse short-term outcomes, but high cortisol concentrations were associated with severe intraventricular hemorrhage, and extremely elevated values were associated with morbidity and death. Low cortisol concentrations alone at these 2 time points did not identify the infants at highest risk for adverse outcomes. In contrast, high cortisol values were associated with increased morbidity and mortality rates. (Source: PEDIATRICS)
Diagnosis of adrenocortical tumor in a neonate by detection of elevated blood 17-hydroxyprogesterone measured as a routine neonatal screening for congenital adrenal hyperplasia: a case report
We report herein a case of prenatally detected neonatal adrenocortical tumor (ACT). The patient was an otherwise healthy newborn girl. No signs of Beckwith-Wiedemann syndrome were identified, and her family medical history did not suggest predisposition to cancer. Computed tomography and ultrasonography after birth revealed a round solid tumor 40 mm in diameter in the right suprarenal area. The precise diagnosis of ACT was unexpectedly obtained based on results from the Japanese neonatal mass screening program. Blood 17-hydroxyprogesterone is routinely measured as a part of this program for early detection of congenital adrenal hyperplasia in Japan. Abnormally elevated level of 17-hydroxyprogesterone was reported in the patient and, thus, led to the diagnosis of ACT. Surgical resection was...
Pregnancies associated with primary adrenal insufficiency
Conclusion(s): AI is often overlooked during pregnancy because of its rarity and pregnancy-like symptoms. Nevertheless, other autoimmune diseases, hyponatremia, metabolic acidosis, nausea and vomiting, and orthostatic hypotension that does not improve with usual treatment or persists after first trimester should evoke a diagnosis of AI. If diagnosis and treatment are properly managed, pregnancy, labor, and delivery may occur without complications. If not, AI is associated with high maternal and fetal morbidity and mortality. (Source: Fertility and Sterility)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Aspects of general medicine.
Authors: Kumana CR
Horizons in Medicine is a series produced annually by the Royal College of Physicians. Volume 19 is based on their Advanced Medicine Conference held in 2007 and offers updates on a wide range of topics in clinical medicine. This 'review of reviews' covers developments described in a selection of chapters. The chapters summarised include: Contemporary management of acute myocardial infarction; Imported infectious disease emergencies; New therapies in the management of type 2 diabetes; Stress and adrenal insufficiency; Making sense of a 'funny thyroid function test'; Myeloproliferative disorders: management and molecular pathogenesis; Drug allergies; Osteoporosis; Rheumatoid arthritis; Understanding migraine from bench to bedside.
PMID: 18840910 [PubMed - in proces...
Perioperative glucocorticosteroid supplementation is not supported by evidence.
Authors: de Lange DW, Kars M
Ever since the first descriptions of adrenal insufficiency following exogenous supplementation physicians dread to abolish perioperative glucocorticosteroid supplementation. Now, 55 years after the first publications we can challenge those first reports. However, these cases have resulted in the supplementation of supraphysiological doses of glucocorticosteroids to patients that use exogenous corticosteroids: the so-called perioperative glucocorticosteroid supplementation or "(gluco)corticosteroid stress scheme". It is very questionable whether a dose that exceeds the normal daily production of 5.7 mg cortisol per square meter of body surface area is necessary to prevent perioperative hypotension. Retrospective, prospective and randomised studies, though al...
Transperitoneal laparoscopic adrenalectomy for metachronous contralateral adrenal metastasis from renal cell carcinoma: a case report
Conclusions: Metachronous contralateral adrenal metastases from primary renal cell carcinoma are very rare but should always be suspected in any nephrectomised patient presenting with an adrenal tumour. Regular followup in these patients accompanied with computed tomography imaging may help the surgeon to detect early lesions. Laparoscopic transperitoneal adrenalectomy is feasible, safe and effective, with minimal trauma to the patient. (Source: BioMed Central)
Which venous system to choose for anastomosis in head and neck reconstructions?
Page: 396DOI: 10.1097/SAP.0b013e3181629a91Authors: Ross, Gary L. MBChB, MD, FRCS (Plast) *; Ang, Erik S. W. FRCS (Glas) *; Golger, Alex MD *; Lannon, Declan FRCS (Plast) *; Addison, Patrick FRCS (Plast) *; Snell, Laura MD *; Novak, Christine B. PT, MS *; Lipa, Joan E. MD, MSc, FRCS(C), FACS +; Gullane, Patrick J. MD, FRCSC, FACS *; Neligan, Peter C. MB, BCh, FRCS (I), FRCSC, FACS * (Source: Annals of Plastic Surgery)
Megestrol: adrenal insufficiency in an elderly patient: case report
(Source: Reactions)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Megestrol: adrenal insufficiency in an elderly patient: case report.
Page: 19 (Source: Reactions Weekly)
[best evidence topic - cardiac general] is steroid therapy ever of benefit to patients in the intensive care unit going into septic shock
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was, is steroid therapy ever of benefit to patients in the intensive care unit going into septic shock? Using the reported search 1505 papers were identified. Fourteen papers represented the best evidence on the subject. The author, journal, date and country of publication, patient group studied, study type, relevant outcomes, results and study comments and weaknesses were tabulated. Recent guidelines from the Surviving Sepsis Campaign recommend using stress doses of corticosteroids for septic shock regardless of adrenal function. All patients undergoing cardiothoracic surgery are at risk of developing septic shock. The 14 papers demonstrated that 28-day mortality is unaffected b...
Comparison of combined aerobic and high-force eccentric resistance exercise with aerobic exercise only for people with type 2 diabetes mellitus.
CONCLUSION:/b> Significant improvements in long-term glycemic control, thigh composition, and physical performance were demonstrated in both groups after participating in a 16-week exercise program. SUBJECTS:in the AE/RE group demonstrated additional improvements in thigh lean tissue and BMI. Improvements in thigh lean tissue may be important in this population as a means to increase resting metabolic rate, protein reserve, exercise tolerance, and functional mobility.
PMID: 18801851 [PubMed - as supplied by publisher] (Source: Physical Therapy)
Opioid and benzodiazepine contributions to etomidate-associated adrenal insufficiency
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s00134-008-1265-7Authors
Jean-François Payen, Albert Michallon Hospital Department of Anesthesiology and Critical Care 38000 Grenoble FranceMarc Vinclair, Albert Michallon Hospital Department of Anesthesiology and Critical Care 38000 Grenoble FranceChristophe Broux, Albert Michallon Hospital Department of Anesthesiology and Critical Care 38000 Grenoble FranceOlivier Chabre, Albert Michallon Hospital Department of Endocrinology 38000 Grenoble France
Journal Intensive Care MedicineOnline ISSN 1432-1238Print ISSN 0342-4642 (Source: Intensive Care Medicine)
Opioid and benzodiazepine contributions to etomidate-associated adrenal insufficiency
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s00134-008-1264-8Authors
Harry Daniell, University of California, Davis Medical School Department of Family Practice 2626 Edith Avenue, Suite A Redding CA 96001 USA
Journal Intensive Care MedicineOnline ISSN 1432-1238Print ISSN 0342-4642 (Source: Intensive Care Medicine)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Management of adrenal insufficiency during the stress of medical illness and surgery.
Authors: Woodforth IJ
PMID: 18803550 [PubMed - in process] (Source: Med J Aust)
[editor's quiz: gi snapshot] right iliac fossa mass with high erythrocyte sedimentation rate in an asian woman
(Source: Gut)
Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1.
In this study, we show that T cells are indispensable to the breakdown of self-tolerance, in contrast to B cells which play a more limited role in autoimmunity. Th1 polarized CD4(+) T cells, in particular, are major contributors to the autoimmune response. With this knowledge, we go on to use therapies targeted at T cells to investigate their ability to modulate disease in vivo. Depletion of CD4(+) T cells using a neutralizing Ab ameliorated the disease process. Thus, therapies targeted specifically at the CD4(+) T cell subset may help control autoimmune disease in patients with APS1.
PMID: 18768863 [PubMed - in process] (Source: Journal of Immunology)
An open sample holder for electrical measurements between 0.1 and 6.0 ghz
J. R. Addison A sample holder for either transmission or reflection measurements is described. Basically a length of fivewire or ''cage'' transmission line, when terminated with a 50 Omega load it exhibits (in air) a residual VSWR of less than 1.05 below 2.0 GHz and (with one exception) less than 1.08 up to 6.0 G ... [Rev. Sci. Instrum. 46, 101 (2008)] published Tue Sep 2, 2008. (Source: Review of Scientific Instruments)
Unexpected endocrine features and normal pigmentation in a young adult patient carrying a novel homozygous mutation in the pomc gene.
Conclusion. Molecular genetic abnormalities of POMC should always be considered in patients with early onset adrenal insufficiency and obesity, even in the presence of normal pigmentation and multiple pituitary hormone anomalies.
PMID: 18765507 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Poor specificity of low growth hormone and cortisol levels during fasting hypoglycemia for the diagnoses of growth hormone deficiency and adrenal insufficiency
CONCLUSIONS. A singe low growth hormone or cortisol value at the time of fasting hypoglycemia has poor specificity for the respective diagnoses of growth hormone deficiency and adrenal insufficiency. (Source: PEDIATRICS)
[electronic pages] skewed x inactivation is associated with phenotype in a female with adrenal hypoplasia congenita
We report a girl with a de novo deletion at Xp21.2 on the maternal chromosome, including DAX1, the GK gene and 3' end of the dystrophin gene, who presented with salt losing adrenal insufficiency and moderate developmental delay, but relatively mild features of muscular dystrophy. Investigation using the androgen receptor as a marker gene identified skewed inactivation of the X chromosome. In the patient’s leucocytes, the paternal X chromosome was completely inactive, but in muscle 20% of the active chromosomes were of paternal origin. Thus skewed X inactivation (deletion on the active maternal X chromosome with an inactive paternal X chromosome) is associated with AHC in a female. Variability in X inactivation between tissues may account for the pronounced salt loss and adrenal insuf...
Megestrol acetate-associated adrenal insufficiency.
Conclusions: This case of adrenal insufficiency in an elderly woman was probably related to MA use. Clinicians should be alert to the possibility of this adverse effect when considering use of MA therapy.
PMID: 18775392 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy)
Endocrinology and the skin.
This article discusses various cutaneous features associated with endocrine disease, which are of general medical relevance. Many of these, such as features associated with hypothyroidism, are common, while others, such as features of adrenal insufficiency, are relatively rare but important.
PMID: 18819297 [PubMed - in process] (Source: British Journal of Hospital Medicine)
Inhaled corticosteroids and adrenal insufficiency: prevalence and clinical presentation.
Page: 769Authors: Molimard, Mathieu 1 2 3; Girodet, Pierre-Olivier 1 3; Pollet, Clothilde 1; Fourrier-Reglat, Annie 1 2 3; Daveluy, Amelie 1 3; Haramburu, Francoise 2 3; Fayon, Michael 1 3 4; Tabarin, Antoine 1 3 (Source: Drug Safety)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Inhaled corticosteroids and adrenal insufficiency: prevalence and clinical presentation
(Source: Drug Safety)
Correspondence: lack of evidence for adrenal insufficiency after single-dose etomidate
(Source: Archives of Surgery)
Correspondence: lack of evidence for adrenal insufficiency after single-dose etomidate--reply
(Source: Archives of Surgery)
Generalized pigmentation due to addison disease.
Generalized pigmentation due to Addison disease.
Dermatol Online J. 2008;14(2):13
Authors: Kumar R, Kumari S, Ranabijuli PK
A 10-year-old boy presented with generalized hyperpigmentation, abdominal pain, change in behavior and, no weight gain for 2 years. On examination, he had hypotension and generalized hyperpigmentation that was more marked on gingival mucosa and frictional sites. Serum cortisol was markedly decreased and his CT scan abdomen showed adrenal atrophy. On the basis of clinical and laboratory findings, a diagnosis of Addison disease was made.
PMID: 18700116 [PubMed - in process] (Source: Dermatol Online J)
The tryptophan 620 allele of the lymphoid tyrosine phosphatase (ptpn22 gene) predisposes to autoimmune addison's disease.
Conclusion: This study confirms the association between the PTPN22 1858T-allele and AAD in an expanded UK cohort and in the previously unstudied Polish population. This meta-analysis allows for the first time a reliable estimate of the strength of effect of this autoimmune disease susceptibility allele across different European Caucasian populations.
PMID: 18710467 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Adrenal insufficiency in sepsis.
Authors: Annane D
The role of the hypothalamic-pituitary adrenal axis in the host response to infection is crucial. The initial inflammatory response to sepsis activates the endogenous release of cortisol, which in turn modulates the synthesis and release of both pro- and anti-inflammatory mediators to restrict inflammation in infected tissues. However, a number of factors, including vascular or ischemic damage, inflammation and apoptosis within the hypothalamic-pituitary adrenal axis, as well as use of drugs that alter cortisol metabolism, may cause adrenal insufficiency. One major problem ICU physicians are faced with is the diagnosis of sepsis-induced adrenal insufficiency at the bedside. A multidisciplinary international task force has recently recommended that sepsis induced adren...
The altered adrenal axis and treatment with glucocorticoids during critical illness.
Authors: Mesotten D, Vanhorebeek I, Van den Berghe G,
Critical illness is generally hallmarked by activation of the hypothalamic-pituitary-adrenal axis. The development of very high levels of cortisol has been associated with severe illness and a raised risk of death. Likewise, a response that is inadequate relative to the degree of stress, termed relative adrenal insufficiency (also known as critical-illness-related corticosteroid insufficiency) has been associated with increased mortality. Much controversy exists with regard to the definition and biochemical testing of an adequate adrenal response to critical illness, which hampers diagnosis. High doses of glucocorticoids have been shown to have no effect in this setting and might be harmful. Moderate doses have been advocated, howe...
Corticotropin tests for hypothalamic-pituitary adrenal insufficiency: a meta-analysis.
Conclusions: Low-dose corticotropin test was superior to standard-dose test for diagnosing chronic HPAI, however it has technical limitations.
PMID: 18697868 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Myosin-vb functions as a dynamic tether for peripheral endocytic compartments during transferrin trafficking
Conclusions:
All results favored the peripheral dynamic tethering hypothesis. (Source: BioMed Central)
pressure is considered high if it is 140 mm Hg and/or 90 mm Hg or higher. High blood pressure increases the risk for heart attack, angina, stroke, kidney failure and peripheral artery disease (PAD). High blood pressure may also increase the risk of developing fatty deposit in arteries (atherosclerosis). The risk of heart failure also increases due to the increased workload that high blood pressure places on the heart.
Abnormal heart valves-Heart valve problems can result from disease, infection or a defect present at birth. When the valves don't open or close completely during each heartbeat, the heart muscle has to pump harder to keep the blood moving. If the workload becomes too great, heart failure results.
Block of arteries-A heart attack is caused by a block of the arteries which minimize the flow of blood with oxygen. Due to little amount of oxygen transported to the brain the stops and the person dies which we call it heart attack. The block of the arteries is a result of blood clot, cholesterol accumulation and fats. That is why doctors advise to eat healthy food with less fat to prevent heart attacks.
Heredity.-People whose parents have coronary artery disease are more likely to develop it. African Americans are also at increased risk, due to their higher rate of severe hypertension than whites.
Treatment
Lower the cholesterol level in your blood. Lowering your cholesterol, especially the level of "bad" LDL cholesterol, keeps plaques from building up in the coronary arteries. The total cholesterol level should be kept below 200 mg/dL, and the LDL cholesterol level below 130 mg/dL (under 100 mg/dL in those with known heart disease or diabetes). Some people are able to control their cholesterol level by changing what they eat, lose weight, and exercise more; others require medication.
Control blood pressure. Uncontrolled high blood pressure is one of the most common causes of heart disease.
Coronary artery bypass grafting is a type of open-heart surgery (the chest is opened). It is sometimes carried out if angioplasty is unsuccessful. It involves rerouting the blood around the affected coronary artery, using a replacement section of a blood vessel - the graft - which is usually taken from a leg vein. This helps people with dangerously narrow coronary arteries, especially if the left side of the heart is not pumping well. For more information, please see the BUPA separate fact sheet
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Celiac disease in patients with type-1 diabetes mellitus screened by tissue transglutaminase antibodies in northwest of iran
Conclusion:&lt;/b&gt; This study showed higher prevalence of CD in patients with T1DM than in general population of northwest Iran and the data lend support to recommend regular screening for CD in all patients with T1DM. (Source: International Journal of Diabetes in Developing Countries)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Get support for celiac disease, gluten free recipes, and moderated discussions by
joining the active community at <a href="http://sensibleceliac.com">The Sensible Celiac</a>.</p>
News from the american chemical society nov. 12, 2008
A faster test for the food protein that triggers celiac disease Researchers in Spain and the United Kingdom are reporting development of a faster test for identifying the food protein that triggers celiac disease, a difficult-to-diagnose digestive disease involving the inability to digest protein called gluten that occurs in wheat, oats, rye, and barley. (Source: Nutrition/Agriculture News From Medical News Today)
Celiac disease: faster gluten test
A new test can detect the gluten protein gliadin in food in 90 minutes versus the current method that takes 8 hours. WebMD Health News (Source: Medscape Medical News Headlines)
Tissue transglutaminase antibodies in individuals with celiac disease bind to thyroid follicles and extracellular matrix and may contribute to thyroid dysfunction
Thyroid Nov 2008, Vol. 18, No. 11: 1171-1178.
Background: Individuals with active celiac disease (CD+) have an increased incidence of thyroid dysfunction, which improves on a gluten-free diet (CD?). We investigated whether tissue transglutaminase-2 IgA antibodies (anti-TGase II) present in sera of ... (Source: Thyroid)
Celiac disease: faster gluten test
Celiac Disease: Faster Gluten Test (Source: eMedicineHealth.com)
Dining guide helps those with gluten problems
A brush with bread can have grave consequences for Janet McKenzie Prince. Prince?s body can?t tolerate some of the proteins in gluten, found in wheat, rye and barley. She's one of an estimated 2 million Americans who can accidentally eat a crouton and end up with digestive issues and problems absorbing nutrients - an autoimmune disorder called celiac disease. (Source: Knoxville News Sentinel: Health and fitness)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Get support for celiac disease, gluten free recipes, and moderated discussions by
joining the active community at <a href="http://sensibleceliac.com">The Sensible Celiac</a>.</p>
Celiac disease: faster gluten test
Scientists have developed a new test that could speed up identification of gluten, a trigger for people with celiac disease. (Source: WebMD Health)
Celiac disease and myointimal proliferation: a possible correlation?
Case Rep Gastroenterol 2008;2:398-404 (DOI:10.1159/000163522) (Source: Karger Publishers)
A faster test for the food protein that triggers celiac disease - analytical chemistry journal
Researchers in Spain and the United Kingdom are reporting development of a faster test for identifying the food protein that triggers celiac disease, a difficult-to-diagnose digestive disease involving the inability to digest protein called gluten that occurs in wheat, oats, rye, and barley. The finding could help millions of people avoid diarrhea, bloating, and other symptoms that occur when they unknowingly eat foods containing gluten. (Source: Crohn's News From Medical News Today)
Spontaneous isolated dissection of the celiac trunk with rupture of the proximal splenic artery: a case report.
We present a case with synchronous rupture of the splenic artery causing massive bleeding and demanding urgent surgery. To our knowledge, only 24 previous cases are reported in the literature. REPORT: The patient was a 56-year-old male smoker with no previous medical history who was treated surgically with exposure of the suprarenal aorta through left-sided medial visceral rotation and isolation of the celiac artery. The origin of the bleeding was identified as a longitudinal rupture of the splenic artery just distal to the hepatic artery. The artery was ligated and splenectomy was performed because of splenic infarction. The hepatic artery was patent and no reconstruction was needed. The postoperative course was uneventful, treatment with antiplatelets and antihypertensive drugs was initi...
Expression of cyclin a in intestinal biopsies from children with celiac disease.
In conclusion, these studies enabled us visualized pattern of distribution of cyclin A but let us also to presume that observed decrease of expression and its distribution might function as additional factor which could be taken under consideration to establish terminal diagnosis. We are aware of the fact that these are very first observations and that this subject needs to be further investigated with the use of additional methods and samples. Key words: celiac disease, cyclin A, immunogold, immunohistochemistry.
PMID: 18999879 [PubMed - in process] (Source: Neoplasma)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Get support for celiac disease, gluten free recipes, and moderated discussions by
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Intraepithelial lymphocytes in duodenum from brazilian adolescents with type 1 diabetes. influence of helicobacter pylori
Conclusions: The density of IELs in the distal duodenum of diabetic adolescents did not differ from that observed in older children and adolescents without this autoimmune disease. H.pylori infection, which is frequent among adolescents from developing countries, did not modify lymphocyte density in the distal duodenum in the absence of lymphocytic gastritis. (Source: Pediatric Diabetes)
Effects of carbon monoxide on trout and lamprey vessels.
Effects of Carbon Monoxide on Trout and Lamprey Vessels.
Am J Physiol Regul Integr Comp Physiol. 2008 Nov 12;
Authors: Dombkowski RA, Whitfield NL, Motterlini R, Gao Y, Olson KR
Carbon monoxide (CO) is endogenously produced by hemoxygenase (HO) and is involved in vascular, neural, and inflammatory responses in mammals. However, the biological activities of CO in non-mammalian vertebrates is unknown. To this extent, we utilized smooth muscle myography to investigate the effects of exogenously applied CO (delivered via a water-soluble CO-releasing molecule, CORM-3) on isolated lamprey (Petromyzon marinus) dorsal aortas and examined its mechanisms of action on trout (Oncorhynchus mykiss) efferent branchial (EBA) and celiacomesenteric (CMA) arteries. CORM-3 dose-dependently relaxed...
A common barrier defect for celiac disease and ulcerative colitis.
A Common Barrier Defect for Celiac Disease and Ulcerative Colitis.
Gastroenterology. 2008 Nov 12;
Authors: Mannon PJ
PMID: 19013169 [PubMed - as supplied by publisher] (Source: Gastroenterology)
Local accumulation and activation of regulatory foxp3+ cd4 tr cells accompanies the appearance of activated cd8 t cells in the liver
Conclusion: Although it contains only a small population of quiescent Foxp3+ CD4 TR cells, the liver can rapidly mobilize and/or recruit this T cell control in response to the intrahepatic appearance of peripherally or locally generated CD8 T blasts. (HEPATOLOGY 2008.) (Source: Hepatology)
Analysis of genomic instability in adult-onset celiac disease patients by microsatellite instability and loss of heterozygosis.
Page: 1159DOI: 10.1097/MEG.0b013e3283094ee9Authors: Fundia, Ariela F. a; Cottliar, Alejandra S. a; La Motta, Graciela b; Crivelli, Adriana b; Gomez, Juan Carlos b; Slavutsky, Irma R. a; Larripa, Irene B. a (Source: European Journal of Gastroenterology & Hepatology)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Get support for celiac disease, gluten free recipes, and moderated discussions by
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Prevalence of celiac disease among patients with behcet?s disease in iran
Conclusion Our findings didn?t support any association between celiac disease and Behcet?s disease in Iranian patients compared to the
general population of Iran.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10620-008-0548-8Authors
Farhad Zamani, Iran University of Medical Sciences Gastrointestinal and Liver Disease Research Center Tehran IranFarhad Shahram, Shariati Hospital, Tehran University of Medical Sciences Rheumatology Research Center Tehran IranRamin Shakeri, Shariati Hospital, Tehran University of Medical Sciences Digestive Disease Research Center North Kargar Ave. Tehran 14117-13135 IranHabib Zayyeni, Shariati Hospital, Tehran University of Medical Sciences Rheumatology Research Center Tehran IranFereydoun Davatchi, Shariati Hospital, Tehran Univer...
Serum zinc in small children with coeliac disease
Conclusion: Serum zinc concentration is decreased in untreated coeliac children with enteropathy and normalizes on gluten-free diet. A low serum zinc value in a child being investigated for possible CD on clinical grounds can thus be used as a complementary marker for enteropathy indicating further investigation with small bowel biopsy. The hypothetical role of zinc in the pathogenesis of CD is discussed. (Source: Acta Paediatrica)
Histological abnormalities of the small bowel mucosa in cirrhosis and portal hypertension.
CONCLUSION: This study provides evidence for the lack of villus atrophy in patients with cirrhosis and portal hypertension, and supports the continuous reliance on the Marsh criteria when the diagnosis of coeliac disease is to be made in the presence of cirrhosis.
PMID: 19009654 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Coeliac disease
(Source: Nutrition and Dietetics)
Reduced diversity and increased virulence-gene carriage in intestinal enterobacteria of children with coeliac disease
Conclusion:
This study has demonstrated that virulence features of the enteric microbiota are linked to coeliac disease. (Source: BMC Gastroenterology)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Get support for celiac disease, gluten free recipes, and moderated discussions by
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Leading dietitian scoops national recognition, epsom general hospital, england
A leading dietitian based at Epsom General Hospital has been crowned 'Dietitian of the Year' by a national charity. Kristina Zaremba who has been working in the field for the past 28 years, said she was delighted with the accolade, awarded to her by Coeliac UK. The charity supports people with coeliac disease - a condition that affects one in 100 people across the UK. (Source: Nutrition/Agriculture News From Medical News Today)
Bifidobacterium strains suppress in vitro the pro-inflammatory milieu triggered by the large intestinal microbiota of coeliac patients
Conclusions:
The intestinal microbiota of CD patients could contribute to the Th1 pro-inflammatory milieu characteristic of the disease, while B. longum ES1 and B. bifidum ES2 could reverse these deleterious effects. These findings hold future perspectives of interest in CD therapy. (Source: BioMed Central)
Increased superoxide levels in ganglia and sympathoexcitation are involved in sarafotoxin 6c-induced hypertension
Endothelin (ET) type B receptors (ETBR) are expressed in multiple tissues and perform different functions depending on their location. ETBR mediate endothelium-dependent vasodilation, clearance of circulating ET, and diuretic effects; all of these should produce a fall in arterial blood pressure. However, we recently showed that chronic activation of ETBR in rats with the selective agonist sarafotoxin 6c (S6c) causes sustained hypertension. We have proposed that one mechanism of this effect is constriction of capacitance vessels. The current study was performed to determine whether S6c hypertension is caused by increased generation of reactive oxygen species (ROS) and/or activation of the sympathetic nervous system. The model used was continuous 5-day infusion of S6c into male Sprague-Dawl...
Ige-mediated cereal allergy and latent celiac disease.
IgE-mediated cereal allergy and latent celiac disease.
J Investig Allergol Clin Immunol. 2008;18(5):412-4
Authors: Torres JA, Sastre J, de las Heras M, Cuesta J, Lombardero M, Ledesma A
PMID: 18973112 [PubMed - in process] (Source: Journal of Investigational Allergology & Clinical Immunology)
Hemosuccus pancreaticus in a patient with celiac trunk aneurysm.
Authors: Fazel I, Asle Soleimani H, Fallah S, Babaei M, Sedighi N, Marashi A, Beniaz F, Malekzadeh R
Celiac artery aneurysm associated with hemosuccus pancreaticus is extremely rare. We herein present a 67-year-old man with a large celiac artery aneurysm presenting with intermittent massive gastrointestinal bleeding due to connection of aneurysm with a blood-filled pancreatic duct who was successfully operated. To the best of our knowledge, this is the first report of a case of hemosuccus pancreaticus due to celiac artery trunk aneurysm.
PMID: 18976038 [PubMed - in process] (Source: Archives of Iranian Medicine)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Get support for celiac disease, gluten free recipes, and moderated discussions by
joining the active community at <a href="http://sensibleceliac.com">The Sensible Celiac</a>.</p>
Regulatory t-cell function is impaired in celiac disease
Abstract Celiac disease (CD) is characterized by intolerance to gluten and high risk of developing autoimmune phenomena. Possible defects
in immune tolerance could have a role in the pathogenesis of the disease. As regulatory T-cells (Tregs) are the main population
involved in maintaining peripheral tolerance, we investigated the number of these cells in celiac patients as compared with
healthy donors. Moreover, we analyzed the suppressive function of CD4+CD25+ T-cells from celiac disease patients and controls
on autologous responder T-cells (CD4+CD25?). The percentage of CD4+CD25+FOXP3+ cells was not different in celiacs and in healthy
controls, and among positive cells the level of expression of the two regulatory markers was comparable. However, the suppressor
activit...
A blinded pilot comparison of capsule endoscopy and small bowel histology in unresponsive celiac disease
This study compares video capsule endoscopy (VCE) with histological specimens of proximal small bowel in patients with celiac
disease who have failed to respond to a gluten-free diet. Patients with nonresponsive celiac disease underwent capsule endoscopy,
and concordance between endoscopy and histology was then calculated using the kappa statistic. In 19 patients, endoscopy videos
were reported as normal in ten (53%) case, as having mild changes in three (16%) cases, and as having moderate-severe changes
in six (31%) cases. Two (11%) had acute ulcers. No small bowel tumors were seen. Endoscopy demonstrated concordance with histological
changes in 14 of the 18 patients with histology available (78% concordance). The kappa statistic suggested a substantial degree
of concordance between...
Celiac axis and superior mesenteric artery: danger zone for left nephrectomy
We report two cases of iatrogenic occlusion of the superior mesenteric artery (SMA) and celiac axis (CA) during left nephrectomy. A patient with a urothelial carcinoma (open surgery) and one with coralliform calculi (laparoscopy) experienced injury to ... (Source: Journal of Endourology)
Alvine pharmaceuticals reports positive results with alv003 in phase 1 trial of therapy in development for celiac disease
Alvine Pharmaceuticals, Inc., today announced proof of concept in a Phase 1 Trial of ALV003, an oral protease therapy in development to detoxify gluten, intended for use by patients with celiac disease. The trial results confirmed that single doses of up to 1,800 mg of ALV003 were safe and tolerable in healthy volunteers. (Source: Health News from Medical News Today)
Noninvasive evaluation of the celiac trunk and superior mesenteric artery with multislice ct in patients with chronic mesenteric ischaemia
Conclusions MSCT angiography can play a major role in the detection of stenosis of the abdominal arteries in patients with suspected CMI.
Content Type Journal ArticleCategory Abdominal Radiology/Radiologia AddominaleDOI 10.1007/s11547-008-0330-1Authors
F. Cademartiri, Azienda Ospedaliero-Universitaria Dipartimento di Diagnostica per Immagine Parma ItalyA. Palumbo, Azienda Ospedaliero-Universitaria Dipartimento di Diagnostica per Immagine Parma ItalyE. Maffei, Azienda Ospedaliero-Universitaria Dipartimento di Diagnostica per Immagine Parma ItalyC. Martini, Azienda Ospedaliero-Universitaria Dipartimento di Diagnostica per Immagine Parma ItalyR. Malagň, Universitŕ degli Studi Dipartimento di Radiologia Verona ItalyM. Belgrano, Universitŕ degli Studi Dipartimento di Radi...<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Get support for celiac disease, gluten free recipes, and moderated discussions by
joining the active community at <a href="http://sensibleceliac.com">The Sensible Celiac</a>.</p>
Peripancreatic lymphatic invasion by pancreatic carcinoma: evaluation with multi-detector row ct
Abstract Peripancreatic lymphatic networks are frequently involved in pancreatobiliary carcinoma, affecting the prognosis. However,
little attention has been paid to CT imaging of normal and pathological conditions of peripancreatic lymphatic networks. We
evaluated multi-detector row CT (MDCT) images of peripancreatic lymphatic networks invaded by pancreatic carcinoma and compared
them with those of normal peripancreatic lymphatic networks using imaging reconstruction every 1 mm with a multiplanar reformation
technique. Apart from the region around the pancreatic body and tail, normal peripancreatic lymphatic networks were detected
as ?linear structures? on MDCT. However, peripancreatic lymphatic invasion by pancreatic carcinoma was frequently identified
as ?ret...
Pancreatic autoantibodies are associated with reactivity to microbial antibodies, penetrating disease behavior, perianal disease, and extraintestinal manifestations, but not with nod2/card15 or tlr4 genotype in a hungarian ibd cohort
Conclusions: PAB autoantibodies in combination with ASCA or anti-glycan antibodies increase the sensitivity for detecting CD, especially isolated colonic CD. Antibody response to PAB was associated with complicated disease phenotype and extraintestinal manifestations in this Eastern European IBD cohort.(Inflamm Bowel Dis 2008) (Source: Inflammatory Bowel Diseases)
Alvine pharmaceuticals reports positive results with alv003 in phase 1 trial of therapy in development for celiac disease
SAN CARLOS, Calif.--(BUSINESS WIRE)--Oct. 29, 2008 - Alvine Pharmaceuticals, Inc., today announced proof of concept in a Phase 1 Trial of ALV003, an oral protease therapy in development to detoxify gluten, intended for use by patients with celiac... (Source: Drugs.com - Clinical Trials)
Influence of previously ingested wheat on fasting breath hydrogen in celiac patients
Abstract The excretion of hydrogen in breath commonly persists, despite an overnight fast. Although the elevation of hydrogen concentration
above the fasting value after the administration of a test sugar is evidence of malabsorption, the level of the fasting value
itself in untreated celiac patients is unknown. Therefore, we studied the fasting breath hydrogen (FBH2) concentration in 40 healthy controls, 35 subjects with functional bowel disorders, and 30 patients of untreated celiac disease
with and without bread or wheat diet one day before the test. The fasting level of hydrogen concentration in untreated celiac
patients (28.7 ± 19.5 ppm) was significantly higher than those in healthy volunteers (9.5 ± 3.4 ppm) and subjects with functional...
Effects of gastric distension and feeding on cardiovascular variables in the shorthorn sculpin (myoxocephalus scorpius).
In conclusion, the response to mechanical distension of the stomach is similar to what we have described in rainbow trout and the postprandial gastrointestinal hyperemia is most likely chemically induced. Key words: postprandial blood flow, coeliaco-mesenteric artery, mechanical stimuli, shunting of blood.
PMID: 18971353 [PubMed - as supplied by publisher] (Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Get support for celiac disease, gluten free recipes, and moderated discussions by
joining the active community at <a href="http://sensibleceliac.com">The Sensible Celiac</a>.</p>
[neurological and psychiatric aspects of some gastrointestinal diseases.]
[Neurological and psychiatric aspects of some gastrointestinal diseases.]
Orv Hetil. 2008 Nov 2;149(44):2079-86
Authors: Aszalós Z
The gastrointestinal tract is controlled by the independent enteric nervous system. It is also closely connected to the central nervous system, and bi-directional communication exists between them. The communication involves neural pathways as well as immune and endocrine mechanisms. The brain-gut axis plays a prominent role in the modulation of gut functions. Signals from different sources (e.g. sound, sight, smell, somatic and visceral sensations, pain) reach the brain. These inputs are modified by memory, cognition and affective mechanisms and integrated within the neural circuits of the central nervous system, spinal cord, autonomic and ent...
Living well with celiac disease?.
Page: 544DOI: 10.1097/MPG.0b013e31817fcb7fAuthors: Hornell, Agneta (Source: Journal of Pediatric Gastroenterology and Nutrition)
Quality of life in adolescents with treated coeliac disease: influence of compliance and age at diagnosis.
Page: 555DOI: 10.1097/MPG.0b013e31817fcb56Authors: Wagner, Gudrun *; Berger, Gabriele *; Sinnreich, Ursula *; Grylli, Vasileia *; Schober, Edith +; Huber, Wolf-Dietrich +; Karwautz, Andreas * (Source: Journal of Pediatric Gastroenterology and Nutrition)
Comparison of a novel whole blood transglutaminase-based elisa with a whole blood rapid antibody test and established conventional serological celiac disease assays.
Page: 562DOI: 10.1097/MPG.0b013e3181615cdeAuthors: Raivio, Tiina *; Korponay-Szabo, Ilma R ***; Paajanen, Tuula *; Ashorn, Merja *,[S]; Iltanen, Sari *; Collin, Pekka +,++; Laurila, Kaija *; Nemes, Eva **; Kovacs, Judit B ++; Carrard, Geraldine [P]; Saramaki, Mika ||; Maki, Markku *,[S]; Kaukinen, Katri *,+,++ (Source: Journal of Pediatric Gastroenterology and Nutrition)
Lymphocytic gastritis and celiac disease in indian children: evidence of a positive relation.
Page: 568DOI: 10.1097/MPG.0b013e31816232a7Authors: Prasad, Kaushal K *; Thapa, Babu R +; Lal, Sadhna +; Sharma, Arun K ++; Nain, Chander K ++; Singh, Kartar ++ (Source: Journal of Pediatric Gastroenterology and Nutrition)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Get support for celiac disease, gluten free recipes, and moderated discussions by
joining the active community at <a href="http://sensibleceliac.com">The Sensible Celiac</a>.</p>
Duodenal bulb biopsies in celiac disease: a multicenter study.
Page: 618DOI: 10.1097/MPG.0b013e3181677d6eAuthors: Bonamico, Margherita *; Thanasi, Enina *; Mariani, Paolo *; Nenna, Raffaella *; Luparia, Rita Pia Lara *; Barbera, Cristiana +; Morra, Isabella +; Lerro, Pietro +; Guariso, Graziella ++; De Giacomo, Costantino [S]; Scotta, Serenella [P]; Pontone, Stefano ||; Carpino, Francesco **; Magliocca, Fabio Massimo **; and the Societa Italiana di Gastroenterologica, Epatologia, e Nutrizione Pediatrica (Source: Journal of Pediatric Gastroenterology and Nutrition)
Gluten measurement and its relationship to food toxicity for celiac disease patients
The gluten analysis of foods has long had limitations, which have precluded food standards authorities from issuing standards for gluten-free foods based on final gluten content. The Codex Alimentarius and the Food and Drug Administration have recently taken steps towards such standards in which they favour the R5-enzyme-linked immunosorbent assay for gluten analysis. If this method is to be widely employed, its limitations should be recognised. Above all, it should be noted the ability of the R5-enzyme-linked immunosorbent assay, and other methods, to measure gluten's toxicity toward celiac disease patients is not validated clinically. Gluten is a complex mixture of proteins and its toxicity is not fully understood. Analytical methods are a valuable tool in the definition of gluten-free f...
Infectious associations of celiac disease.
Infectious associations of Celiac disease.
Autoimmun Rev. 2008 Oct 28;
Authors: Plot L, Amital H
Infectious agents have been implicated in the pathogenesis of many autoimmune diseases. Celiac disease (CD) is an autoimmune disorder affecting patients with a specific genetic predisposition (HLA-DQ2, HLA-DQ8) who are exposed to gluten, the major storage protein of wheat and similar grains. An environmental factor, such as an infectious agent, is thought to precipitate the disease via various pathogenic mechanisms, such as molecular mimicry, resulting in modulation of the host's immune tolerance. There is evidence that CD is related to perinatal infections, and that maternal-milk may have a protective role. Observations imply that there is a relationship between viral infections su...
[original articles] investigation of molecular markers in the diagnosis of refractory coeliac disease in a large patient cohort
Conclusions:
This study supports the use of phenotypic and T cell clonality investigations in identifying patients with true rCD. (Source: Journal of Clinical Pathology)
Pediatric and adolescent medicinefrontiers in celiac disease
(Source: Acta Paediatrica)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Get support for celiac disease, gluten free recipes, and moderated discussions by
joining the active community at <a href="http://sensibleceliac.com">The Sensible Celiac</a>.</p>
Efficacy of endoscopic ultrasound (eus) guided celiac plexus block (cpb) for managing abdominal pain associated with chronic pancreatitis (cp): a meta-analysis.
Page: 477DOI: 10.1097/01.MPA.0000335485.84721.6bAuthors: Kaufman, M. S. 1; Singh, G. 1; Das, S. 2; Erber, J. A. 1; Micames, C. 3; Cristescu, B. 1; Gress, F. G. 1 (Source: Pancreas)
Efficacy of endoscopic ultrasound (eus) guided celiac plexus neurolysis (cpn) for managing abdominal pain associated with pancreatic cancer: a meta-analysis.
Page: 496DOI: 10.1097/01.MPA.0000335391.53014.98Authors: Singh, G. 1; Kaufman, M. 1; Das, S. 2; Gress, F. 1 (Source: Pancreas)
Protective effects of glycyrrhizin in a gut hypoxia (ischemia)-reoxygenation (reperfusion) model
Conclusions This study demonstrates that glycyrrhizin exerts multiple protective effects in splanchnic artery occlusion?reperfusion shock.
Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-008-1334-yAuthors
Rosanna Di Paola, IRCCS Centro Neurolesi ?Bonino-Pulejo? Messina ItalyMarta Menegazzi, University of Verona Biochemistry Division, Department of Neuroscience and Vision Verona ItalyEmanuela Mazzon, IRCCS Centro Neurolesi ?Bonino-Pulejo? Messina ItalyTiziana Genovese, IRCCS Centro Neurolesi ?Bonino-Pulejo? Messina ItalyConcetta Crisafulli, Policlinico Universitario Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica 98123 Messina ItalyMartina Dal Bosco, IRCCS Centro Neurolesi ?Bonino-Pulejo? Messina ItalyZ...
Plasma exchange for anti-gad associated non paraneoplastic limbic encephalitis.
Plasma exchange for anti-GAD associated non paraneoplastic limbic encephalitis.
Transfus Apher Sci. 2008 Oct 25;
Authors: Mazzi G, Roia DD, Cruciatti B, Matà S, Catapano R
Limbic encephalitis (LE) is a neurological syndrome usually presenting in a paraneoplastic form. Recently many cases were reported with no concurring neoplasia, presenting with specific antibodies for voltage-gated potassium channel or for neuronal membrane antigens. Anti-glutamic acid decarboxylase (GAD) antibodies act against GABAergic receptors of the central nervous system. These antibodies were found in coeliac disease serum and in neurologic patients. We are reporting a case of a 21-year-old coeliac woman manifesting complex multiple-daily partial drug-resistant seizures for 7 years. The diagnosis ...
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